Thanks, in part, to the generous support of the NIHCM, this month we are releasing four special episodes on Opioids. We hope you enjoy them. This week’s episode: The Science of Opioids – How…
35 responses to “The Science of Opioids”
@ 6:37 dude is trying to steal a car so he can get more opioids.
15 years very real pain 300 mg oxy per day, only helpful. stop panting a negative, as one day your life just might need some help with pain, in fact only people with pain! should be talking about pain, and the help pain meds can give, nothing like a healthy person telling us about pain and the effects of pain meds that help with it!!!
I had kidney stones & they gave me oxycodone to relieve the pain. It's the best pain relief medicine I ever had. I saved a few of those pills for when I was having back pain etc. They work like a charm & I wish I could find a place to buy them. It's to bad so many people abused them & now so hard to get. Also I felt that I was more awake & felt like I was smarter when I took them.
thank the limbic system. yea, for not welcoming poisons with long term severely crippling effects. what's wrong with our limbic systems! let's all ban together and do something about these scandalous limbic systems! They are clearly the evil ones in this equation!
I know a guy off the web who assisted me when I couldn’t get my prescriptions. He worked off the dark web and it was easy when he delivered.+1(507)556 1573 message him He’s trustworthy
Thanks very much for a great video! The auto captions failed a few times, (Mew vs. Mu and more). Also, auto captions don't do sentence structure well, no caps and no punctuation.
Here is a simple way to increase endogenous opioid activity in the brain.
HYPOTHESIS: Dopaminergic activity will stimulate endogenous opioid systems when the latter are in a non-suppressed state.
EXPLANATION AND ‘PROOF’: Activity that involves continuous positive act/outcome discrepancy or novelty (productive or meaningful behavior) while the covert musculature is inactive (a resting state) will result in heightened feeling of pleasure and arousal, or ‘eudaemonia’, ‘flow’, or ‘peak’ experience. This derives from the observation that neuro-muscular tension (or stress) inhibits endogenous opioid (pleasure) release, while relaxation accentuates it, the latter permitting opioid systems to be further stimulated by dopaminergic activity (arousal) elicited by meaningful behavior.
The reason this explanation does not appear evident from general observation is that its counterpart as ‘flow’ or ‘peak’ experience is described through literary metaphor and not scientific language and obscures the independent and dependent measures that accurately describe it. The virtue of this explanation is that it is easily testable by anyone. Just get into a relaxed state (mindfulness protocols are the best way to do this) and then exclusively pursue or anticipate pursuing productive activity for periods of a half hour or so, and voila, you will have a flow or eudaemonic experience. It is that simple.
I offer a more detailed explanation in pp. 47-52, and pp 82-86 of my open source book on the neuroscience of resting states, ‘The Book of Rest’, linked below.
This above book is based on the research of the distinguished neuroscientist Kent Berridge of the University of Michigan, a preeminent researcher and authority on dopamine, addiction, and motivation, who was kind to vet the work for accuracy and endorse the finished manuscript.
If people were better educated and told everything they need to know and look out for with opiods they arnt an issue. Most of the over use I've seen is from people thinking they just keep taking them if there's pain. Doc gave me it so must be fine. If you have an understanding and ability to control yourself any drug be be taken safely.
Wait. Dont we know now that tolerance comes from receptor down-regulation and lower binding capability as a result. Causing stuff like glutamate & substance P to be neurologically amped up in expectation of an opioid dose. much like neurological counterbalancing to alcohol. This counterbalancing resulting in overexcitation from those chemicals resulting in withdrawal symptoms? Or is this still just a theory
Can you show people what happens when you smoke weed.. you are only born with x amount of brain cells & pain meds do not kill brain cells.. but, hey.. tax this & bet you it will fly like weed
*HUOMIO!!! SUOMALAISET Kandin klopit ja muut terveysalalla työskentelevät suosittelen teille tätä videota. Kiitos! Bangkok-Jomppa* https://youtu.be/g3vDMTsuGuQ
HUOMIO!!! SUOMALAISET Kandin klopit ja muut terveysalalla työskentelevät suosittelen teille tätä videota. Kiitos! Bangkok-Jomppa https://youtu.be/g3vDMTsuGuQ
1. Opioids have a half life. Say for Hydrocodone, the half-life, the amount of time it takes for the level in your blood to become half, is 4 hours (It's really about 3.6 hours). The usual prescription is hydrocodone 10/325 1-2 every 4 hours with a maximum daily dose of 8/day. Problem : Take 2 when you wake up at 06:00 really achy. At 10:00, when your blood serum level is at 10, you take 2 more, bringing your blood serum level to 30. At 14:00, when your blood serum level is at 15 you take 2 more, bringing your blood serum level to 35. At 16:00, when your blood serum level is 17.5, you take 2 more, bringing your blood serum level to 27.5, you are expected to make it through the night, another 14 hours, on this level of pain relief. The proof the drug companies are at fault is this prescription regimen.
2. Opioids became a problem because the drug companies published an addictive regimen.
3. Yet, we have to ask the question, how does emotional pain become interpreted as physical pain ? We see this whenever an inability for individuals, especially male, no longer have the ability to achieve a sense of mastery and autonomy as has happened in counties west of me had their jobs sent to Chinese sweatshops? These counties now have very serious problems with drugs an alcoholism.
I wrote a book about my struggle with opiate addiction(the horrors I went through)and how I was able to beat it. It offers understanding, wisdom, and hope! If someone has kindle they can read it free! Please pass it on! https://www.amazon.com/Such-Unfortunates-Andrew-Mann-ebook/dp/B07S9LJRTZ
@ 6:37 dude is trying to steal a car so he can get more opioids.
They feel good. You don’t even need pain
“Nyorons”
How the hell did anyone find out any of this
15 years very real pain 300 mg oxy per day, only helpful. stop panting a negative, as one day your life just might need some help with pain, in fact only people with pain! should be talking about pain, and the help pain meds can give,
nothing like a healthy person telling us about pain and the effects of pain meds that help with it!!!
Legalize fentanyl
I had kidney stones & they gave me oxycodone to relieve the pain. It's the best pain relief medicine I ever had. I saved a few of those pills for when I was having back pain etc. They work like a charm & I wish I could find a place to buy them. It's to bad so many people abused them & now so hard to get. Also I felt that I was more awake & felt like I was smarter when I took them.
thank the limbic system. yea, for not welcoming poisons with long term severely crippling effects. what's wrong with our limbic systems! let's all ban together and do something about these scandalous limbic systems! They are clearly the evil ones in this equation!
I was totally following along then WHOOOOO … WHAT TF really? That crazy spider was unnecessary. Then the needles I lost it THANkS
Chaine spécialisé en cours de médecine https://youtu.be/uqtnWbZvbHg
Gr8 video 🙂
I know a guy off the web who assisted me when I couldn’t get my prescriptions. He worked off the dark web and it was easy when he delivered.+1(507)556 1573 message him
He’s trustworthy
Thanks very much for a great video! The auto captions failed a few times, (Mew vs. Mu and more). Also, auto captions don't do sentence structure well, no caps and no punctuation.
Here is a simple way to increase endogenous opioid activity in the brain.
HYPOTHESIS: Dopaminergic activity will stimulate endogenous opioid systems when the latter are in a non-suppressed state.
EXPLANATION AND ‘PROOF’: Activity that involves continuous positive act/outcome discrepancy or novelty (productive or meaningful behavior) while the covert musculature is inactive (a resting state) will result in heightened feeling of pleasure and arousal, or ‘eudaemonia’, ‘flow’, or ‘peak’ experience. This derives from the observation that neuro-muscular tension (or stress) inhibits endogenous opioid (pleasure) release, while relaxation accentuates it, the latter permitting opioid systems to be further stimulated by dopaminergic activity (arousal) elicited by meaningful behavior.
The reason this explanation does not appear evident from general observation is that its counterpart as ‘flow’ or ‘peak’ experience is described through literary metaphor and not scientific language and obscures the independent and dependent measures that accurately describe it. The virtue of this explanation is that it is easily testable by anyone. Just get into a relaxed state (mindfulness protocols are the best way to do this) and then exclusively pursue or anticipate pursuing productive activity for periods of a half hour or so, and voila, you will have a flow or eudaemonic experience. It is that simple.
I offer a more detailed explanation in pp. 47-52, and pp 82-86 of my open source book on the neuroscience of resting states, ‘The Book of Rest’, linked below.
https://www.scribd.com/doc/284056765/The-Book-of-Rest-The-Odd-Psychology-of-Doing-Nothing
This above book is based on the research of the distinguished neuroscientist Kent Berridge of the University of Michigan, a preeminent researcher and authority on dopamine, addiction, and motivation, who was kind to vet the work for accuracy and endorse the finished manuscript.
Berridge’s Site
https://sites.lsa.umich.edu/berridge-lab/
also:
Meditation and Rest
from the International Journal of Stress Management, by this author
https://www.scribd.com/doc/121345732/Relaxation-and-Muscular-Tension-A-bio-behavioristic-explanation
If people were better educated and told everything they need to know and look out for with opiods they arnt an issue. Most of the over use I've seen is from people thinking they just keep taking them if there's pain. Doc gave me it so must be fine. If you have an understanding and ability to control yourself any drug be be taken safely.
Wait. Dont we know now that tolerance comes from receptor down-regulation and lower binding capability as a result. Causing stuff like glutamate & substance P to be neurologically amped up in expectation of an opioid dose. much like neurological counterbalancing to alcohol.
This counterbalancing resulting in overexcitation from those chemicals resulting in withdrawal symptoms?
Or is this still just a theory
Milk
Can you show people what happens when you smoke weed.. you are only born with x amount of brain cells & pain meds do not kill brain cells.. but, hey.. tax this & bet you it will fly like weed
im morphine snd high off oxy takinh a poop rn
That spider scare was a low blow y'all. Not cool, editing-person!
Interesting
This is the most perfect video Ive found about opioids really, so greatly detailed
Is nobody gonna talk about the subject rather than that spider?
every comment is about the spider LOL
They cause hallucination or noy
Anyone else watching this debating whether they should pour up or not?
*HUOMIO!!! SUOMALAISET Kandin klopit ja muut terveysalalla
työskentelevät suosittelen teille tätä videota. Kiitos! Bangkok-Jomppa*
https://youtu.be/g3vDMTsuGuQ
HUOMIO!!! SUOMALAISET Kandin klopit ja muut terveysalalla työskentelevät suosittelen teille tätä videota. Kiitos! Bangkok-Jomppa
https://youtu.be/g3vDMTsuGuQ
Too technical.
Good but misses the main issue.
1. Opioids have a half life. Say for Hydrocodone, the half-life, the amount of time it takes for the level in your blood to become half, is 4 hours (It's really about 3.6 hours). The usual prescription is hydrocodone 10/325 1-2 every 4 hours with a maximum daily dose of 8/day. Problem : Take 2 when you wake up at 06:00 really achy. At 10:00, when your blood serum level is at 10, you take 2 more, bringing your blood serum level to 30. At 14:00, when your blood serum level is at 15 you take 2 more, bringing your blood serum level to 35. At 16:00, when your blood serum level is 17.5, you take 2 more, bringing your blood serum level to 27.5, you are expected to make it through the night, another 14 hours, on this level of pain relief. The proof the drug companies are at fault is this prescription regimen.
2. Opioids became a problem because the drug companies published an addictive regimen.
3. Yet, we have to ask the question, how does emotional pain become interpreted as physical pain ? We see this whenever an inability for individuals, especially male, no longer have the ability to achieve a sense of mastery and autonomy as has happened in counties west of me had their jobs sent to Chinese sweatshops? These counties now have very serious problems with drugs an alcoholism.
Tolerance sucks * throws morphine in the trash * there has to be a better way for pain management 🧐
Don't tell me about that kappa receptor..salvia works on that one and yeah its not fun. Give me more of the Mu one 😉
so hard to understand
I wrote a book about my struggle with opiate addiction(the horrors I went through)and how I was able to beat it. It offers understanding, wisdom, and hope! If someone has kindle they can read it free! Please pass it on! https://www.amazon.com/Such-Unfortunates-Andrew-Mann-ebook/dp/B07S9LJRTZ
For opioid tolerance consider down regulation of the receptor themselves.